[Blood serum cholecystokinin and clinical-functional variability of biliary pathology].

RESULTS: Basal and stimulated serum CCK concentrations were not statistically significant differences (p > 0.05) with the control group in patients studied in the whole and in patients subgroups, formed by the diagnosis of biliary pathology and the character of gallbladder emptying. Increased stimulated CCK concentration was found in patients with symptomatic variants. Reduce of serum-cholecystokinin concentration growth (ACCK) after intake of Sorbitol was revealed in subgroup of patients with low-symptom variant. Reduced sensitivity of the gallbladder to CCK was observed in subgroups of patients with gallbladder hypokinetic dyskinesia and one with symptomatic variant of biliary pathology. CONCLUSION: The sensitivity of the gallbladder neuromuscular apparatus to CCK is associated with clinical and functional variability of the biliary pathology.

[Vegetotropic therapy and hypobaric hypoxic adaptation in gallbladder motor dysmotility].

The study of 67 chronic biliary patients (36 - gallbladder dysfunction, 25 acalculuous cholecystitis, 6 - cholelithiasis) was revealed their functional dysadaptation characterized by gallbladder dysmotility and autonomic dysfunction. Vegetotropic therapy (Propranolol, Metoclopramid, Atropine) according to the autonomic regulation activity has advantages in correction of the gallbladder dysmotility in comparison to the routine pharmacotherapy. Hypobaric hypoxic adaptation results in the increase of gallbladder emptying that opens perspectives for the non-pharmacological correction of the gallbladder hypokinetic dyskinesia.

[Indices of cholecystokinin secretion, vegetative regulation of heart rate and anxiety level in patients with a motor dysfunction of the gallbladder]. / Pokazateli sekretsii kholetsistokinina, vegetativnoi reguliatsii serdechnogo ritma i uroven' trevozhnosti u bol'nykh s motornoi disfunktsiei zhelchnogo nuzyria.

We examined 36 patients with biliary diseases (14 men and 22 women) at the age of 19-62 (19 patients with chronic non-calculous cholecystitis, 11 patients with cholelithiasis, and 6 patients with gallbladder dysfunctions) as well as 14 practically healthy people from the control group. Methods of the study included dynamic sorbite echography of the gallbladder, determination of serum cholecystokinin by the radioimmunoassay (RIA) as well as examination of variability of the cardiac rate and anxiety level. Patients with a motor dysfunction of the gallbladder suffer from disorders of the correlation between cholecystokinin secretion, the functional state of the vegetative nervous system and the nature of the motor and evacuation function of the gallbladder.

[Effect of vegetotropic pharmacologic preparations of the motor-evacuatory function of the gallbladder in patients with chronic biliary tract pathology]. / Vliianie vegototropnykh farmakologicheskikh preparatov na motorno-évakuatornuiu funkstiiu zhelchnogo puzyria u bol'nykh s khronicheskoi patologiei biliarnogo trakta.

We examined 74 patients at the age of 18-54 with a chronic bilary pathology, including 50 patients with chronic non-calculous cholecystitis, 16 patients with a gallbladder dysfunction, and 8 patients with cholelithiasis. The differentiated correction of the motor gallbladder dysfunction can be carried out on the basis of the analysis of heart rate variability parameters and results of the gallbladder dynamic sorbite echography against the background of the action of vegetotropic pharmacological preparations (Atropine, Propranolol, Metoclopramide, Hymecromone, Cisapride, Amitriptyline).

[Indicators of cholecystokinin secretion, vegetative regulation of cardiac rhythm, and level of anxiety in patients with motor dysfunction of the gall bladder]. / Pokazateli sekretsii kholetsistokinina, vegetativnoi reguliatsii serdechnogo ritma i uroven' trevozhnosti u bol'nykh s motornoi disfunktsiei zhelchnogo puzyria.

We examined 36 patients with biliary diseases (14 males and 22 females) at the age of 19-62 (19 with chronic acalculous cholecystitis, 11 with cholelithiasis, 6 with gall-bladder dysfunction) and 14 practically healthy people as a control group. The examination methods comprised dynamic gall-bladder ultrasonography with Sorbitol, serum cholecystokinin detection with the help of radioimmunoassay, cardiac rate variability and anxiety level tests. Patients with motor gall-bladder dysfunction have derangements of interrelations between cholecystokinin secretion, the functional state of the vegetative nervous system, and the nature of the gall-bladder motor evacuation function.

[Assessment of autonomic maintenance of the activity related to the gallbladder emptying in patients with biliary pathology]. / Otsenka vegetativnogo obespecheniia deiatel'nosti, sviazannoi s oporozhneniem zhelchnogo puzyria, u bol'nykh biliarnoi patologiei.

A group of 110 patients (51 men and 59 women) with biliary pathologies (71 patients with chronic non-calculous cholecystitis and 39 patients with gallbladder dysfunctions) was examined. The control group included 45 practically healthy people. There was a parallel study of gallbladder emptying by the dynamic ultrasonography method with 20.0 g of Sorbitum and spectrum analysis of the heart rate variability. The vegetative maintenance of the activity associated with gallbladder emptying in patients with biliary pathologies is characterized by the strengthened activity of the sympathetic nervous system and suprasegmented cerebral centers of the ergotropic orientation; at the same time the parasympathetic activity prevails in healthy people.

[Choice of optimal vegetotropic drug therapy in patients with chronic non-calculous cholecystitis combined with gallbladder dyskinesia]. / Vybor optimal'noi vegetotropnoi farmakoterapii u bol'nykh khornicheskim nekal'kuleznym kholetsitom v sochetanii s diskineziei zhelchnogo puzyria.

The group of 117 patients (58 male and 57 female, age from 17 to 54) with chronic non-calculous cholecystitis was examined. The control group included 54 practically healthy persons. The motor-evacuation function of gallbladder was estimated on dynamic ultrasonographic findings of biliary system sorbet. The character of the autonomic regulation was determined on the basis of variability parameters of the heart rhythm. The results of the repeated dynamic ultrasonography of biliary system with sorbet on a background of vegetotropic medications (Atropine, Propranolol, Metoclopramide) have demonstrated that the variability parameters of heart rhythm can be used for an estimation of the autonomic regulation type and can become the basis of vegetotropic pharmacotherapy choice for the patients with chronic non-calculous cholecystitis and biliary dyskinesia.

[A choice of optimal vegetotropic pharmacotherapy in patients with chronic non-calculous cholecystitis in combination with dyskinesia of the gallbladder]. / Vybor optimal'noi vegetotropnoi farmakoterapii u bol'nykh khronicheskim nekal'kuleznym kholetsistitom.

The group of 117 patients (58 male and 57 female, age from 17 to 54) with chronic non-calculous cholecystitis was examined. The control group included 54 practically healthy persons. The motor-evacuation function of gallbladder was estimated on dynamic ultrasonographic findings of biliary system sorbet. The character of the autonomic regulation was determined on the basis of variability parameters of the heart rhythm. The results of the repeated dynamic ultrasonography of biliary system with sorbet on a background of vegetotropic medications (Atropine, Propranolol, Metoclopramide) have demonstrated that the variability parameters of heart rhythm can be used for an estimation of the autonomic regulation type and can become the basis of vegetotropic pharmacotherapy choice for the patients with chronic non-calculous cholecystitis and biliary dyskinesia.